The Timucua rebel against the Spanish in a final resistance movement, after suffering huge losses due to Spanish invasion, slave labor, and disease. A Timucua chief known as Lucas Menendez calls for a rebellion and kills all soldiers and civilians at the San Pedro Mission. The Spaniards retaliate and sell the remaining Timucua survivors into slavery; some escape into other Indigenous communities, becoming part of the Seminoles of Florida (Nies, 1996).